The student winners of the 2021 Demetriades - Tsafka - Kokkalis Prizes were announced at the end of this academic year. David Brown, advised by Professor Viviana Gradinaru and Professor Matt Thomson has received the prize in Entrepreneurship. His research is in molecular and computational strategies for both understanding variability in the human immune system, and characterizing the on- and off-target profile of gene therapy delivery at the resolution of individual cells. Hsiao-Yi Chen, advised by Professor Marco Bernardi has received the prize in Nanotechnology. His research is in the development of ab initio methods to investigate exciton radiative emission and ultrafast dynamics. Tatyana Dobreva, advised by Professor Matt Thomson and Professor Viviana Gradinaru has received the prize in Entrepreneurship. Her research is in single-cell sequencing to interrogate the human immune system, characterize immune response to recombinant Adeno-Associated Viruses (AAVs), and engineer immune cells. Zachary Lee, advised by Professor Steven Low has received the prize in Environmentally Benign Renewable Energy Sources. His research involves developing a suite of tools and algorithms to enable smart electric vehicle charging at scale. Valère Lambert, advised by Professor Nadia Lapusta has received the prize in Seismo-Engineering, Prediction, and Protection. His research is in developing and using physics-based numerical models that combine laboratory insight and theoretical developments to simulate sequences of earthquake ruptures and slow slip that match field observations, thus illuminating physical properties of faults and building towards predictive modeling.